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Clinical and[18F]dopa PET Findings in Early Parkinson's Disease JNNP 59:597-600, Morrish,P.K.,et al, 1995 See this aricle in Pubmed Article Abstract Twenty seven patients with recent onset(mean symptom duration 22(SD 14) months,Hoehn and Yahr score 1-8(SD 0-7)Parkinson's disease were studied with{F}dopa PET.There was a correlation between putamen influx(Ki)and clinical rating,but not symptom duration.Symptom onset was estimated at a putamen Ki of between 57%and 80%of normal.Most ipsilateral putamen Ki values in early asymmetric Parkinson's disease fell within the normal range.The implication is that either the disease is not established in the ipsilateral putamen or that the technique is insufficiently sensitive to detect it.Discrimination analysis completely separated the normal and Parkinson's disease cohorts,but when a discriminant function from a previous study was used predictively four of the 27 patients with Parkinson's disease were incorrectly classified as normal.

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(click to filter results - removes previous filter) CAT scan,emission CAT scan,emission,abnormal Parkinson disease Parkinson disease,early symptoms Parkinson disease,presymptomatic detection preclinical

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